C-reactive protein (CRP), the classic acute-phase of human serum, is synthesized by hepatocytes. Normally, it is present only in trace amounts in serum, but it can increase as much as l,000-fold in response to injury or infection. The clinical measurement of CRP in serum therefore appears to be a valuable screening test for organic disease and a sensitive index of disease activity in inflammatory, infective and ischemic conditions. MacLeod and Avery found that antibody produced against purified CRP provided a more sensitive test than the Cpolysaccharide assay. Since that time a number of immunological assays have been devised to measure CRP such as capillary precipitation, double immunodiffusion and radical immunodiffusion. The major advantage of this method is the rapid two (2) minute reaction time.
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